Autoimmunity in dengue pathogenesis

Controversies in dengue pathogenesis

Research into the pathogenesis of dengue fever has exploded over the last half-century, with issues that were considered simple becoming more complex as additional data are found. This has led to the development of a number of controversies that are being studied across the globe and debated in the literature. In this paper, the following six controversies are analysed and, where possible, res...

Autoimmunity in Dengue Virus Infection: Chapter 07

Dengue haemorrhagic fever (DHF) is a complicated disease associated with viral and immune pathogenesis. There is still no effective vaccine to prevent the progression of DHF because of its undefined pathogenic mechanisms. The generation of autoimmunity in dengue virus (DEN) infection has been implicated in dengue pathogenesis. Based on our previous studies showing antibodies (Abs) against DEN n...

Pathogenesis of autoimmunity in common variable immunodeficiency

Common variable immunodeficiency (CVID) presents in up to 25% of patients with autoimmune (AI) manifestations. Given the frequency and early onset in some patients with CVID, AI dysregulation seems to be an integral part of the immunodeficiency. Antibody-mediated AI cytopenias, most often affecting erythrocytes and platelets make up over 50% of these patients. This seems to be distinct from mai...

Xenogeneic Thymus Transplantation Pathogenesis of Autoimmunity After

Autoimmunity and the pathogenesis of myocarditis.

T he ability to distinguish between self versus nonself is the most salient feature of the immune system. It is of vital importance for the immune system to mount vigorous humoral and cellular responses to foreign antigens. On the other hand, it is equally important for the immune system to be tolerant against self-antigens. Tolerance can be maintained either by physical elimination (clonal del...